Scanning fast and slow: current limitations of 3 Tesla functional MRI and future potential
Aug 4, 2016
How can fMRI acquisition and analysis be improved for functional connectivity studies? What populations are hard to scan reliably? Which areas of the brain are troublesome? Here is a great review from one group’s perspective. Do you agree with the authors? Did they miss something?
Scanning fast and slow: current limitations of 3 Tesla functional MRI and future potential journal.frontiersin.org
“Functional MRI at 3T has become a workhorse for the neurosciences, e.g., neurology, psychology, and psychiatry, enabling non-invasive investigation of brain function and connectivity. However, BOLD-based fMRI is a rather indirect measure of brain function, confounded by physiology related signals, e.g., head or brain motion, brain pulsation, blood flow, intermixed with susceptibility differences close or distant to the region of neuronal activity. Even though a plethora of preprocessing strategies have been published to address these confounds, their efficiency is still under discussion. In particular, physiological signal fluctuations closely related to brain supply may mask BOLD signal changes related to “true” neuronal activation. Here we explore recent technical and methodological advancements aimed at disentangling the various components, employing fast multiband vs. standard EPI, in combination with fast temporal ICA. Our preliminary results…”
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